Introducing Xenopus!

Over the past couple of weeks, you might have encountered men of all ages, proudly wearing a freshly grown moustache. During the month of November, many men take part in Movember, an annual event which involves growing a moustache to raise awareness around men’s health and in particular men’s mental health and prostate and testicular cancer. World-wide Movember foundations raise money and organise events with the aim of increasing early cancer detection, diagnosis and effective treatments. While raising awareness and increasing early detection may prevent many deaths, a better comprehension…

Comments Off on Introducing Xenopus!

Get to know Bionomous: the interview

On November 19th, Bionomous celebrated two years of existence. For this special event, Bionomous’ team has interviewed Frank and Ana, the co-founders of Bionomous, to get a better insight into what it took to bring the EggSorter to life, start a company as well as the projects they have in mind for the future. If you are interested in knowing more about how Bionomous was founded, read on! https://youtu.be/6Qs22R-syBk What is Bionomous? What do you do? Frank: Bionomous is a swiss start-up that was born at the Ecole Polytechnique Fédérale…

Comments Off on Get to know Bionomous: the interview

Caudal fin regeneration in zebrafish

Halloween is right around the corner and you will soon be seeing various spooky creatures parading down the streets: ghosts, wizards and zombies which might even be missing a limb. While ghosts and wizards are usually classified as magical creatures, zombies have something in them which make them slightly more real. A zombie is an animated corpse which has been brought back to life and although resurrection remains completely unreal, regenerative medicine has been working on replacing and regenerating defective cells, tissues and organs with the goal of restoring normal function. Some animals…

Comments Off on Caudal fin regeneration in zebrafish

Studying breast cancer with zebrafish: a case study

In this new series of articles, we will review some of the key scientific publications of 2020 which included zebrafish in their studies. This first review will cover an article published in Clinical Cancer Research on March 15th 2020: Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein that Promotes TGFβ-induced breast cancer metastasis1.In this article, the authors have focused their research on a subset of proteins involved in the tumour cell intracellular degradation pathway as a potential treatment for breast cancer. To get a full comprehensive overview of the…

Comments Off on Studying breast cancer with zebrafish: a case study

Small model organisms

Over the past years, zebrafish have proven to be excellent model systems for a wide panel of experiments. We have discussed throughout our previous articles their advantages and disadvantages, how they could be incorporated to various research fields and different automation techniques which facilitate their handling in laboratories. Today we will discuss 4 other model organisms: Drosophila melanogaster, Xenopus laevis, Caenorhabditis elegans and Arabidopsis thaliana, all have in common their genetic similarity to humans, their ease of care and prolific breeding. While this last feature is particularly useful for studies requiring…

Comments Off on Small model organisms

Studying zebrafish behaviour: robotics and automation

In today's article we will take a step back from zebrafish embryos and discuss how adult zebrafish collective behaviours can be studied using robotic systems.Danio rerio, commonly known as zebrafish is a small but robust cyprinid, commonly found in food plains of the south of Asia, particularly India. They thrive in shallow and slow flowing-waters and can generally be found in standing water bodies, often connected to rice cultivation. This is most likely due to the high content of zooplankton in rice cultivations, a major component of the zebrafish diet. Zebrafish…

Comments Off on Studying zebrafish behaviour: robotics and automation

Morphological and phenotypic characteristics of zebrafish embryos

In our modern world, development of new synthetic compounds and chemicals is essential for many industries, such as the pharmaceutical, clothing and food industries. This has become a major public and environmental issue as many of these compounds can be toxic and detrimental to human and animal health. In addition to these artificial toxins, chemicals can occur naturally in the environment such as heavy metals or nitrates. Although it is widely recognised that such compounds can cause damage to life, how harmful they are and how they cause disease needs…

Comments Off on Morphological and phenotypic characteristics of zebrafish embryos

Zebrafish early embryo sorting

Over the past 20 years, the use of zebrafish in the lab has dramatically increased. In 2000, PubMed displayed 657 articles when searching for “zebrafish”. In 2020, that number shot up to 3’979 publications (1). This is most likely due to the many advantages zebrafish represent as an animal model (and which are resumed in our article What are zebrafish). Particularly, their high breeding capacity is a very interesting asset for experiments requiring large sample sizes. Zebrafish can indeed produce up to 300 embryos weekly, hence why they are referred…

Comments Off on Zebrafish early embryo sorting

Artificial Intelligence for zebrafish egg sorting

Artificial intelligence always triggers a lot of curiosity when mentioned around a dinner table. AI brings in mind to a lot of people the latest fantastic movie released in the cinema with cool robots and futuristic computer systems. In reality and up until today, AI is really the science of giving to a material device the ability to show cognitive behaviour similarly to humans in order to learn and solve complex problems. AI is very present in our everyday lives and its development and achievements made in various fields is…

Comments Off on Artificial Intelligence for zebrafish egg sorting

High-throughput screening and automation technologies for zebrafish assays

Although zebrafish have been described numerous times as ideal organism models, manual handling of zebrafish embryos can turn out to be complex and time consuming due to their small size and the large quantities of samples usually required in an experimental setup (1). To increase efficiency of such studies, it has been crucial to develop fast and automated screening methods.  In this article we will discuss various high-throughput screening methods and automation technologies which have been developed and proven to be very helpful for zebrafish embryo and larval assays. What…

Comments Off on High-throughput screening and automation technologies for zebrafish assays