Using zebrafish for water quality control

Water pollution is evolving into a serious human and environmental health problem. Numerous pollutants can be found in waters, including synthetic compounds, chemicals naturally present in the environment and endocrine disruptors. To ensure good water quality and safe consumption, drinking water must be certified free of these toxins. An effective and accurate quality control system is therefore essential. Over the past few years, zebrafish have made their way into this field and can now be used as in-vivo water quality control systems. To find out more, read on! Environmental health…

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Women’s contribution to zebrafish science

February 11th marked the 7th International Day of Women and Girls in Science. The purpose of this day is to recognise the role of women in science and to promote full and equal access to science to all women and girls who wish to participate and take part in leading actions and innovations around the world. At Bionomous, we recognise the power and value of women and we have gathered in this article a bit of history of women in science, several contributions of women to research in general, and…

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How zebrafish can help tackle cervical cancer

Cervical cancer is the fourth most common malignancy diagnosed in women and causes 270’000 deaths every year1. In 2008, the Nobel Prize of medicine was awarded to Dr. Herald zur Hausan – a German virologist and medical doctor – for his work and discoveries on HPV causing cervical cancer2. His discoveries led to a worldwide joint effort by virologists, epidemiologists, molecular biologists and clinicians to tackle the disease by preventing viral infection through the development of efficient prophylactic vaccines for HPV3. Vaccines are highly efficient and prevent the majority of…

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Get to know Bionomous: the interview

On November 19th, Bionomous celebrated two years of existence. For this special event, Bionomous’ team has interviewed Frank and Ana, the co-founders of Bionomous, to get a better insight into what it took to bring the EggSorter to life, start a company as well as the projects they have in mind for the future. If you are interested in knowing more about how Bionomous was founded, read on! https://youtu.be/6Qs22R-syBk What is Bionomous? What do you do? Frank: Bionomous is a swiss start-up that was born at the Ecole Polytechnique Fédérale…

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Introducing Xenopus!

Over the past couple of weeks, you might have encountered men of all ages, proudly wearing a freshly grown moustache. During the month of November, many men take part in Movember, an annual event which involves growing a moustache to raise awareness around men’s health and in particular men’s mental health and prostate and testicular cancer. World-wide Movember foundations raise money and organise events with the aim of increasing early cancer detection, diagnosis and effective treatments. While raising awareness and increasing early detection may prevent many deaths, a better comprehension…

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Caudal fin regeneration in zebrafish

Halloween is right around the corner and you will soon be seeing various spooky creatures parading down the streets: ghosts, wizards and zombies which might even be missing a limb. While ghosts and wizards are usually classified as magical creatures, zombies have something in them which make them slightly more real. A zombie is an animated corpse which has been brought back to life and although resurrection remains completely unreal, regenerative medicine has been working on replacing and regenerating defective cells, tissues and organs with the goal of restoring normal function. Some animals…

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Zebrafish larvae as a model to decision-making processes – a case study

We make thousands of decisions every day. It has been estimated that we make around 220 decisions each day only related to food (1). Choice is fundamental for our lives, as well as for the behaviour of all the other animals. Making a decision requires to integrate physiological and psychological information to choose a course of action or a belief among several available options.Understanding the mechanisms by which animals integrate information from their senses over space and time to make sensory-motor decisions is at the core of the reviewed article…

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Precise spatiotemporal genome editing in Zebrafish using CRISPR/Cas9

Since 1901, Nobel Prizes have been awarded to “those who, during the preceding year, have conferred the greatest benefit to humankind”, in Alfred Nobel’s words1. Last year, Emmanuelle Charpentier and Jennifer Doudna were awarded with this recognized prize in the field of chemistry for their contributions to the genetic engineering tool known as CRISPR/Cas92.CRISPR/Cas9 has been extensively studied and meticulously developed during these last years for efficient and precise genome editing. In this article, we will review the scientific paper: Spatiotemporal Control of CRISPR/Cas9 Function in Cells and Zebrafish using…

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Zebrafish as a model to study the toxicity of different pesticides – a case study

Since 1974, World Environment Day has been celebrated every year on 5 June, so this month we want to acknowledge this event by reviewing a scientific article where zebrafish are used to test the toxicity of certain pesticides: Toxicity of Deltamethrin to Zebrafish Gonads Revealed by Cellular Biomarkers 1, published in Journal of Marine Science and Engineering on January 23th, 2020.This article investigates the chronic effects of deltamethrin, a synthetic insecticide extensively used in pest control, on gonads. For doing so, the authors of the mentioned article exposed zebrafish adults…

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Zebrafish to study a broken heart: macrophages’ implication in scar formation after a heart attack

In this series of articles, we review some of the key scientific publications of 2020 which included zebrafish in their studies. This review will cover an article published in Nature Communications on January 30th, 2020: Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair1.This article challenges the current model of scarring after a heart attack and implicates macrophages, a type of white blood cell of the immune system, as direct contributors to collagen deposition during this process.Heart attack and heart failureScarring process after a…

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