Get to know Bionomous: the interview

On November 19th, Bionomous celebrated two years of existence. For this special event, Bionomous’ team has interviewed Frank and Ana, the co-founders of Bionomous, to get a better insight into what it took to bring the EggSorter to life, start a company as well as the projects they have in mind for the future. If you are interested in knowing more about how Bionomous was founded, read on! https://youtu.be/6Qs22R-syBk What is Bionomous? What do you do? Frank: Bionomous is a swiss start-up that was born at the Ecole Polytechnique Fédérale…

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Bionomous has been granted an InnoSuisse project

Bionomous has been awarded an InnoSuisse project to collaborate with the Swiss research center CSEM. Having started the 1st of November, the InnoSuisse project aims at developing new modules compatible with Bionomous' current EggSorter to optimize and improve zebrafish embryo handling in an automatic fashion. In collaboration with CSEM we will work on the validation of our current technology and the modifications needed for the release of a final version of the EggSorter by the end of 2022.  The project also covers the development of new modules for zebrafish embryo…

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1st Lausanne Fish User Meeting

Bionomous sponsored the 1st Lausanne Fish User Meeting Last Friday 5th of November, the 1st Lausanne Fish User Meeting took place. Bionomous was one of the sponsors of the event, and Frank Bonnet, CEO and co-founder at Bionomous, and Ana Hernando, CMO and co-founder were present. The event was wonderfully organised. It was composed of different talks where the different groups using fish as a model for research presented their projects. And we say fish, yes ! As in addition to zebrafish, there was also a group using killifish, so…

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1st Lausanne Fish User Meeting

Bionomous is sponsoring the 1st Lausanne Fish User Meeting ! Next Friday 5th of November, the Lausanne community for fish research will meet for the first time. This event aims at bringing together all the groups doing research with fish in Lausanne to discuss the different topics that they study. The fish research community in Lausanne is mainly focused on zebrafish, and we also have some groups using killifish for studies in the areas of epigenetics, stem cells, aging. At Bionomous we decided to sponsor this great event since we…

Caudal fin regeneration in zebrafish

Halloween is right around the corner and you will soon be seeing various spooky creatures parading down the streets: ghosts, wizards and zombies which might even be missing a limb. While ghosts and wizards are usually classified as magical creatures, zombies have something in them which make them slightly more real. A zombie is an animated corpse which has been brought back to life and although resurrection remains completely unreal, regenerative medicine has been working on replacing and regenerating defective cells, tissues and organs with the goal of restoring normal function. Some animals…

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Zebrafish larvae as a model to decision-making processes – a case study

We make thousands of decisions every day. It has been estimated that we make around 220 decisions each day only related to food (1). Choice is fundamental for our lives, as well as for the behaviour of all the other animals. Making a decision requires to integrate physiological and psychological information to choose a course of action or a belief among several available options.Understanding the mechanisms by which animals integrate information from their senses over space and time to make sensory-motor decisions is at the core of the reviewed article…

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Precise spatiotemporal genome editing in Zebrafish using CRISPR/Cas9

Since 1901, Nobel Prizes have been awarded to “those who, during the preceding year, have conferred the greatest benefit to humankind”, in Alfred Nobel’s words1. Last year, Emmanuelle Charpentier and Jennifer Doudna were awarded with this recognized prize in the field of chemistry for their contributions to the genetic engineering tool known as CRISPR/Cas92.CRISPR/Cas9 has been extensively studied and meticulously developed during these last years for efficient and precise genome editing. In this article, we will review the scientific paper: Spatiotemporal Control of CRISPR/Cas9 Function in Cells and Zebrafish using…

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Zebrafish as a model to study the toxicity of different pesticides – a case study

Since 1974, World Environment Day has been celebrated every year on 5 June, so this month we want to acknowledge this event by reviewing a scientific article where zebrafish are used to test the toxicity of certain pesticides: Toxicity of Deltamethrin to Zebrafish Gonads Revealed by Cellular Biomarkers 1, published in Journal of Marine Science and Engineering on January 23th, 2020.This article investigates the chronic effects of deltamethrin, a synthetic insecticide extensively used in pest control, on gonads. For doing so, the authors of the mentioned article exposed zebrafish adults…

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Zebrafish to study a broken heart: macrophages’ implication in scar formation after a heart attack

In this series of articles, we review some of the key scientific publications of 2020 which included zebrafish in their studies. This review will cover an article published in Nature Communications on January 30th, 2020: Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair1.This article challenges the current model of scarring after a heart attack and implicates macrophages, a type of white blood cell of the immune system, as direct contributors to collagen deposition during this process.Heart attack and heart failureScarring process after a…

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Man-made chemicals PFAS surround us, and you did not even know about their toxic effect: what zebrafish can tell us

In this series of articles, we review some of the key scientific publications of 2020 which included zebrafish in their studies. This second review will cover an article published in Environmental Health Perspective on April 9th 2020: Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS1.In this article, the authors have studied the toxicology of different PFAS, short for poly and perfluoroalkyl substances, which are substances widely present in our daily life.PFAS and concerns about their useGrouping PFAS based on shared toxicity…

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