Caudal fin regeneration in zebrafish

Halloween is right around the corner and you will soon be seeing various spooky creatures parading down the streets: ghosts, wizards and zombies which might even be missing a limb. While ghosts and wizards are usually classified as magical creatures, zombies have something in them which make them slightly more real. A zombie is an animated corpse which has been brought back to life and although resurrection remains completely unreal, regenerative medicine has been working on replacing and regenerating defective cells, tissues and organs with the goal of restoring normal function. Some animals…

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Zebrafish to study a broken heart: macrophages’ implication in scar formation after a heart attack

In this series of articles, we review some of the key scientific publications of 2020 which included zebrafish in their studies. This review will cover an article published in Nature Communications on January 30th, 2020: Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair1.This article challenges the current model of scarring after a heart attack and implicates macrophages, a type of white blood cell of the immune system, as direct contributors to collagen deposition during this process.Heart attack and heart failureScarring process after a…

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