Although zebrafish have been described numerous times as ideal organism models, manual handling of zebrafish embryos can turn out to be complex and time consuming due to their small size and the large quantities of samples usually required in an experimental setup (1). To increase efficiency of such studies, it has been crucial to develop fast and automated screening methods.  In this article we will discuss various high-throughput screening methods and automation technologies which have been developed and proven to be very helpful for zebrafish embryo and larval assays. What…