In the USA, January is characterized by creativity. In fact, the creativity month celebrates outside-the-box-thinking, the expression of ourselves and the innovations. To match with this idea, we decided to highlight some original uses of zebrafish and related technologies, for which researchers have had to be creative. Some of them are: the use of zebrafish as environmental sensors, as a model to study microbiome-host interactions, as a tool for personalized medicine, on the possible uses of artificial intelligence, and finally, on a double mutant strain called “casper”.  Zebrafish as environmental…